The four teams in Group H will finally make their World Cup debuts Tuesday, while Russia and Egypt will battle it out for second place in Group A.
Friday's three-game slate is highlighted by the big Spain v. Portugal match, but RotoWire's Andrew Laird explains why it might be a game to ignore for fantasy purposes.
Uruguay are significant favorites to win Group A, but the bigger story line will be whether Russia can avoid being just the second host nation to not reach the knockout rounds.