Tyreek Hill and De'Von Achane both are questionable, and their numbers might disappoint even if they play given Miami's slew of injury concerns along the offensive line.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
Clyde Edwards-Helaire is poised to handle a lead role for the first time since Week 4 of 2022.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
Rhamondre Stevenson is the centerpiece of a broken offense, and this should be one of his better weeks thanks to Sunday's matchup with another last-place team.
Playing at home and against the Bears, the Week 11 setup couldn't be much easier for Amon-Ra St. Brown.
DeAndre Hopkins should be able to get rolling against a struggling and injured Tampa Bay corner rotation.
Nico Collins and Tank Dell should come roaring out of the bye week against a battered and weak Carolina secondary.
The Vikings face a simple reality Sunday: either Jordan Addison has a strong game, or the Minnesota passing game falls apart.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
The Dolphins are looking to bring a shootout to the Bills, but Stefon Diggs is prepared to shoot back against Miami's questionable pass defense.
Christian Kirk should maintain momentum against a Houston defense without two of its top three corners, including their slot defender.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
The Colts' cornerback personnel is weak but their run defense is strong, setting up a feast for Calvin Ridley and the Jags passing game.