Fair or not, all the pressure is on Jalen Hurts as the Eagles try to stop their slide in Tampa Bay.
Josh Allen and the Bills offense have struggled lately, but the Miami defense has been a reliable punching bag for Allen.
Jaren Hall should find it easy to get the ball to Justin Jefferson against Green Bay's weakened corner rotation.
Ezekiel Elliott might be a heavy road underdog, but he should still see plenty of work against Denver.
Dallas Goedert could get going Monday night, especially if rainy conditions make it difficult to throw downfield.
Gus Edwards' usage could turn for the better if weather forces the Ravens to run more than usual Sunday night.
AJ Dillon needs to show more, but the friendly Giants run defense could help him do just that Monday.
Tyreek Hill is on a blistering pace in 2023 and the Titans pose no obvious way to slow him down.
For Dak Prescott to stay in the MVP conversation he'll need to stay hot against Philadelphia on Sunday.
Trevor Lawrence will try to make it three strong games in a row as the home-team Jags face Cincinnati.
The Vikings' blitzing tendencies versus Justin Fields' big-play ability could make for a boom-or-bust proposition Monday.
Keenan Allen gets a tough matchup against the Ravens on Sunday, but the Chargers have nowhere else to throw the ball.
Tyreek Hill struggled against the Jets in 2022, but the Dolphins were without Tua Tagovailoa for both of those games.
DeVonta Smith has been in A.J. Brown's shadow all year, but with Dallas Goedert out Philadelphia needs both WRs to produce Monday.
T.J. Hockenson has been unstoppable for Minnesota since Justin Jefferson's injury, setting up another big game against Denver.
The 5-4 Bills can't afford to lose to Denver on Monday, so Josh Allen and the Bills offense should play with urgency.
The Jets are favored yet struggle to throw the ball, setting up Breece Hall for a productive game on the road.
Justin Herbert is the primary reason the Chargers are favored on the road, but the Jets defense could make things challenging.
The Bengals passing game is roaring into form, which might require another active game from Bills TE Dalton Kincaid.
The Raiders defense is much friendlier than the Ravens one, and Jared Goff will likely bounce back Monday.
Austin Ekeler has been slow to restart since returning from injury, but the Bears have allowed big pass-catching numbers to RBs.
With no Deebo Samuel the 49ers are dependent on a big game from Brandon Aiyuk on Monday, and they'll likely get it.
The Eagles offense is poised for a big game Sunday, which could prompt Tyreek Hill to maintain his historic 2,300-yard pace in response.
All eyes are on Austin Ekeler as he returns from a high ankle sprain, and the Chargers desperately need him to produce.
Saquon Barkley is risky in his return from a high ankle sprain, but it's difficult to identify any other Giants targets as heavy road underdogs.
It's been a bumpy ride for Jordan Love through four games, but a friendly Raiders defense could provide relief.
Deebo Samuel is reportedly over his rib and knee injuries, making him a candidate to make more noise against Dallas.
After a bumpy start to the season, Daniel Jones should put up good fantasy production against Seattle on Monday.
Patrick Mahomes might be costly, but in a low-scoring matchup he's more affordable than usual in the Sunday night showdown slate.
All eyes are on Joe Burrow as he attempts to play through his calf injury.